Formulation and Evaluation of Polyherbal Emulgel

Jitendra Kandale; Jaiprakash Sangshetti; Ganesh Dama; Jayant Bidkar; Ramraja Umbare; Gauri Ghangale

doi:10.52756/ijerr.2023.v30.027

Jitendra Kandale Y.B. Chavan College of Pharmacy, Aurangabad, Maharashtra- 431003, India; SVERI’s College of Pharmacy, Pandharpur, Maharashtra - 413304, India https://orcid.org/0009-0009-5487-1876
Jaiprakash Sangshetti Y.B. Chavan College of Pharmacy, Aurangabad, Maharashtra- 431003, India https://orcid.org/0000-0002-9064-4111
Ganesh Dama Sharadchandra Pawar College of Pharmacy, Pune, Maharashtra- 412409, India https://orcid.org/0000-0002-4993-6841
Jayant Bidkar Sharadchandra Pawar College of Pharmacy, Pune, Maharashtra- 412409, India https://orcid.org/0000-0002-8574-314X
Ramraja Umbare K. T. Patil College of Pharmacy, Osmanabad, Maharashtra - 413501, India https://orcid.org/0000-0002-9708-9093
Gauri Ghangale Amrutvahini College of Pharmacy, Sangamner, Maharashtra - 422608, India https://orcid.org/0009-0008-8345-3991

DOI: https://doi.org/10.52756/ijerr.2023.v30.027

Keywords: Emulgel, Glycyrrhiza glabra, herbal formulation, Ocimum sanctum, Punica granatum, Rubia cordifolia

Abstract

The foible of allopathic medicines has resulted in adopting herbal plants that have been proven cost-effective with fewer adverse effects. Thus, the evaluation of the potential of herbal plants for the formulation of innovative dosage forms has resulted in the cure of various disease conditions. Thus, in context, the main aim of this work was to formulate the topical emulgel using herbal extracts of Ocimum sanctum, Rubia cordifolia, Glycyrrhiza glabra and Punica granatum. Emulgel was prepared by use of 23 factorial designs and the influence of the type of the gelling agent on viscosity and drug release from the prepared emulgel was investigated. The results found that the EG7 formulation was the optimized batch with pH of 6.3±0.02, viscosity of 5998.7±1.2 mPas, drug release of 89.75± 3.5% and in terms of stability. The results indicated the emulgel formulations were successful concerning all of the parameters.

References

Chellathurai, B. J., Anburose, R., Alyami, M. H., Sellappan, M., Bayan, M. F., Chandrasekaran, B.,Chidambaram, K. &Rahamathulla, M. (2023).Development of a Polyherbal Topical Gel for the Treatment of Acne.Gels.,9(2), 163. https://doi.org/10.3390/gels9020163

Dubey, S., & Dixit, A. K. (2023). Preclinical evidence of polyherbal formulations on wound healing: A systematic review on research trends and perspectives. Journal of Ayurveda and Integrative Medicine, 14(2), 100688. https://doi.org/10.1016/j.jaim.2023.100688

Gupta, A. (2022). Fundamentals of skin wound healing and repair: A brief review on cellular and molecular pathophysiologic basis of wound healing. Natural Polymers in Wound Healing and Repair, pp.1-18.https://doi.org/10.1016/B978-0-323-90514-5.00017-1

Kavitha, K. S., Baker, S., Rakshith, D., Kavitha, H. U., YashwanthaRao, H. C., Harini, B. P., &Satish, S. (2013). Plants as green source towards synthesis of nanoparticles.Int. Res. J. Biol. Sci., 2(6), 66-76.

Khan, A. D., Rastogi, V., Lavhale, P. M., & Jain, J. (2022). Novel approaches for herbal drug delivery in wound healing: A review. Indian Journal of Pharmaceutical Sciences, 84(2), 247-260. https://doi.org/10.36468/pharmaceutical-sciences.918

Rajad, S., Karodi, R., Dhanake, K., Kohakde, S., & Bendre, S. (2023). Formulation And Evaluation of Polyherbal Mouth Ulcer Gel Containing Bombax ceiba Thorn Extract and Psidium guajava Leaf Extract. Journal of Coastal Life Medicine, 11, 845-857.

Rathi, V., Pal, R., &Sandhu, K. S. (2022). Formulation and evaluation of serum containing polyherbal extracts of cinnamomum cassia & Aloe vera for the treatment of wound infection. Journal of Advanced Medical and Dental Sciences Research, 10(8), 104-109.

Rieger, S., Zhao, H., Martin, P., Abe, K., &Lisse, T. S. (2015). The role of nuclear hormone receptors in cutaneous wound repair. Cell Biochemistry and Function, 33(1), 1-13. https://doi.org/10.1002/cbf.3086

Rogers, C., &Gobbi, A. (2017).The Optimization of Natural Healing.Bio-orthopaedics: A New Approach, 3-24. https://doi.org/10.1007/978-3-662-54181-4_1

Saxena, M., & Kishore, K. (2022).Pharmacological Evaluation of Polyherbal Formulation for Wound Healing Activity in Rats.World Journal of Pharmaceutical Research, 11(3), 1447-1458.

Sohail, T., Khan, R. A., Imran, H., Fareed, G., &Yasmeen, S. (2022). Development and Evaluation of Antimicrobial Poly-herbal Gel Formulation for the Treatment of Various Skin Infections. RADS Journal of Pharmacy and Pharmaceutical Sciences, 10(3), 92-99.

Stadelmann, W. K., Digenis, A. G., & Tobin, G. R. (1998). Physiology and healing dynamics of chronic cutaneous wounds. The American Journal of Surgery, 176(2), 26S-38S. https://doi.org/10.1016/S0002-9610(98)00183-4

Tanimu, H., Vijayan, N. K., &Sukumaran, B. O. Polyherbal Formulation Approach: A Promising Wound Healing Startegy.(2022). Int. J. Life Sci. Pharma Res., 12(5), P126-142. https://doi.org/10.22376/ijpbs/lpr.2022.12.5.P126-142

Umadevi, A., Kumari, C., Kumar, P. A., Am, H. S. N., Divya, K., & Hisana, P. V. (2018). Development and evaluation of polyherbal gel for antifungal activity. International Journal of Current Pharmaceutical Research, 10(5), 40-43. https://doi.org/10.22159/ijcpr.2018v10i5.29694

Versteeg, H. H., Heemskerk, J. W. M., Levi, M., &Reitsma, P. H. (2013).New fundamentals in coagulation. Physiol. Rev., 93, 327-358. https://doi.org/10.1152/physrev.00016.2011