Investigation for determination of therapeutic potential for antitubercular activity with special reference to Caesalpinia crista fruits

Vipul Dhasade; M. Komala

doi:10.52756/ijerr.2023.v30.029

Vipul Dhasade Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Chennai - 600117,Tamil Nadu, India https://orcid.org/0000-0002-0959-9465
M. Komala Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Chennai - 600117,Tamil Nadu, India https://orcid.org/0000-0001-8357-535X

DOI: https://doi.org/10.52756/ijerr.2023.v30.029

Keywords: Alkaloids, antitubercular activity, Caesalpinia crista, MABA

Abstract

In recent years, plant biochemistry has played a significant role due to plant-derived products' phytochemical details. One of the difficulties of phytochemistry nowadays is performing the aforementioned procedures with limited material due to the wide variety and low yield of phytochemicals. The secondary metabolites found in Caesalpinia crista have a wide range of applications. To better understand the antitubercular properties of Caesalpinia crista, a major medicinal plant, this study examines the most essential compounds in its fruits. Results from both quantitative and phytochemical screening revealed high concentrations of a wide variety of bioactive compounds, including alkaloids, phenols, amino acids, flavonoids, saponins, tannins, proteins, terpenoids, and glycosides. Microplate-based Alamar blue assay demonstrates their efficacy against TB. In addition, the results confirmed the presence of antitubercular potential in specific phytochemicals extracted from Caesalpinia crista fruits.

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