A Clinical Study of Allergy and COPD Correlation With Spirometric and FENO Evaluation

Hemalata Dange; Rupali Patil; Chandrashekhar Upasani

doi:10.52756/ijerr.2023.v34spl.013

Hemalata Dange SNJB’s (Gurukul) Shriman Sureshdada Jain College of Pharmacy, Neminagar, Chandwad, Nashik, Maharashtra, India https://orcid.org/0009-0009-2470-4401
Rupali Patil Mahatma Gandhi Vidyamandir’s Pharmacy College, Mumbai-Agra Road, Nashik, Maharashtra, India https://orcid.org/0000-0002-7291-2370
Chandrashekhar Upasani SNJB’s (Gurukul) Shriman Sureshdada Jain College of Pharmacy, Neminagar, Chandwad, Nashik, Maharashtra, India https://orcid.org/0000-0003-4446-1557

DOI: https://doi.org/10.52756/ijerr.2023.v34spl.013

Keywords: Allergens, COPD, FENO, Spirometry, SPT

Abstract

Occurrence of allergies & asthma increased in India and may be the top public health concern. The risk of allergies and other allergic diseases might grow with on-going exposure to allergens. There are various unusual allergies, including natural rubber latex, pollen, dust, medications (including antibiotics), food, fungus spores, insect and mite excrement, insect bites and stings (and their venom). The not unusual allergens which might be chargeable for respiratory troubles have been diagnosed after a sincere attempt. A take-look study was conducted on one hundred fifteen patients to assess hypersensitivity and COPD correlation. Their medical histories have been accrued to examine whether or not they were exposed to unique allergens or no longer in the past. All the individuals underwent a Skin Prick Test (SPT) with selected allergens to assess allergens exposure. Patient's Spirometry and FENO check statistics were collected for COPD prognosis. Most COPD patients showed mild to extreme allergic reactions to various allergens.

References

Ambrosino, P., Fuschillo, S., Accardo, M., Mosella, M., Molino, A., Spedicato, G. A., ... & Maniscalco, M. (2022). Fractional Exhaled Nitric Oxide (FeNO) in Patients with Stable Chronic Obstructive Pulmonary Disease: Short-Term Variability and Potential Clinical Implications. Journal of Personalized Medicine, 12(11), 1906. https://doi.org/10.3390/jpm12111906

Bao, W., Zhang, X., Yin, J., Han, L., Huang, Z., Bao, L., ... & Zhang, M. (2021). Small-airway function variables in spirometry, fractional exhaled nitric oxide, and circulating eosinophils predicted airway hyperresponsiveness in patients with mild asthma. Journal of Asthma and Allergy, 415-426. https://doi.org/10.2147/JAA.S295345

Cottini, M., Bondi, B., Bagnasco, D., Braido, F., Passalacqua, G., Licini, A., ... & Paoletti, G. (2023). Impulse oscillometry defined small airway dysfunction in asthmatic patients with normal spirometry: Prevalence, clinical associations, and impact on asthma control. Respiratory Medicine, 218, 107391. https://doi.org/10.1016/j.rmed.2023.107391

Dange, H. V., & Patil, R. A. (2021). Involvement of some allergens of plant and animal origin in allergic reactions related to respiratory system. Journal of Medical Pharmaceutical and Allied Sciences, 1(1947), 67-74. https://doi.org/10.22270/jmpas.VIC1I1.1947

Dey, S., & Guha, P. (2020). A brief review on cigarette induced cellular. International Journal of Experimental Research and Review, 23, 18-26. https://doi.org/10.52756/ijerr.2020.v23.002

Karmaus, W., Kheirkhah Rahimabad, P., Pham, N., Mukherjee, N., Chen, S., Anthony, T. M., ... & Jones, A. D. (2023). Association of Metabolites, Nutrients, and Toxins in Maternal and Cord Serum with Asthma, IgE, SPT, FeNO, and Lung Function in Offspring. Metabolites, 13(6), 737. https://doi.org/10.3390/metabo13060737

Kellerer, C., Wagenpfeil, S., Daines, L., Jörres, R. A., Hapfelmeier, A., & Schneider, A. (2021). Diagnostic accuracy of FeNO [fractional exhaled nitric oxide] and asthma symptoms increased when evaluated with a superior reference standard. Journal of Clinical Epidemiology, 129, 86-96. https://doi.org/10.1016/j.jclinepi.2020.09.021

Kostorz-Nosal, S., Jastrzębski, D., Błach, A., & Skoczyński, S. (2023). Window of opportunity for respiratory oscillometry: A review of recent research. Respiratory Physiology & Neurobiology, 104135.https://doi.org/10.1016/j.resp.2023.104135

Li, Y., Huang, K., Li, W., Peng, Y., Tang, X., & Yang, T. (2023). Validation of a new portable system containing both FeNO analysis and spirometry measurement. Frontiers in Medicine, 10. https://doi.org/10.3389%2Ffmed.2023.1210329

Maiti, M., & Samanta, G. (2018). Relationship between physical activity and smoking behavior among college students. International Journal of Experimental Research and Review, 15, 39-43. https://doi.org/10.52756/ijerr.2018.v15.006

Matsunaga, K., Kuwahira, I., Hanaoka, M., Saito, J., Tsuburai, T., Fukunaga, K., ... & on Pulmonary, J. R. S. A. (2021). An official JRS statement: The principles of fractional exhaled nitric oxide (FeNO) measurement and interpretation of the results in clinical practice. Respiratory Investigation, 59(1), 34-52. https://doi.org/10.1016/j.resinv.2020.05.006

Nakwan, N., Ruklerd, T., Perkleang, T., & Taptawee, P. (2022). The levels and correlations of FeNO, blood eosinophils and lung function in well-controlled asthma. Advances in Respiratory Medicine, 90(3), 183-192. https://doi.org/10.5603/ARM.a2022.0015

Navuluri, N., Lagat, D., Egger, J. R., Birgen, E., Diero, L., Murdoch, D. M., ... & Paul, D. (2023). Asthma, Airflow Obstruction, and Eosinophilic Airway Inflammation Prevalence in Western Kenya: A Population-Based Cross-Sectional Study. International Journal of Public Health, 68, 1606030. https://doi.org/10.3389/ijph.2023.1606030

Nawaz, S. F., Ravindrarn, M., & Kuruvilla, M. E. (2022). Asthma diagnosis using patient-reported outcome measures and objective diagnostic tests: now and into the future. Current Opinion in Pulmonary Medicine, 28(3), 251-257. https://doi.org/10.1097/MCP.0000000000000871

Sarkar, B., Biswas, P., Acharya, C.K., Ghorai, S.K., Nahar, N., Jana, S.K., Ghosh, S., Sarkar, D., Behera B. K., & Madhu, N.R. (2021). Knowledge of Traditional Indian Medicinal Plants for the Management of COPD. Chettinad Health City Medical Journal, 10(4), 184 – 189. https://doi.org/10.36503/chcmj10(4)-05

Sarkar, B., Biswas, P., Acharya, C.K., Jana, S.K., Nahar, N., Ghosh, S., Dasgupta, D., Ghorai, S. K., & Madhu, N.R. (2022). Obesity Epidemiology: A Serious Public Health Concern in India. Chettinad Health City Medical Journal, 11(1), 21-28. https://doi.org/10.24321/2278.2044.202205

Tamura, K., Shirai, T., Hirai, K., Nakayasu, H., Takahashi, S., Kishimoto, Y., ... & Kato, S. (2022). Mucus plugs and small airway dysfunction in asthma, COPD, and asthma-COPD overlap. Allergy, Asthma & Immunology Research, 14(2), 196. https://doi.org/10.4168%2Faair.2022.14.2.196

Ulrik, C. S., Lange, P., & Hilberg, O. (2021). Fractional exhaled nitric oxide as a determinant for the clinical course of asthma: a systematic review. European Clinical Respiratory Journal, 8(1), 1891725. https://doi.org/10.1080/20018525.2021.1891725