Cancer therapy with Vinca Alkaloids
Keywords:
Antimitotic, Catharanthus roseus, chemotherapy, Vinca alkaloids
Abstract
Vinca alkaloids are well known antimitotic or antimicrotubule agents, originally derived from the medicinal plant Catharanthus roseus (Apocynacea) and other Vinca plants. They have a wide spectrum of anticancer activity both in vitro and in vivo. The most important members of this family are vinblastine and vincristine (naturally occurring), and their semisynthetic derivatives viz., vindesine, vinorelbine, vinflunine, which were approved by FDA as drugs in cancer therapy. They are used alone or in combination with other anticancer agents for the treatment of a variety of cancers including leukemias, lymphomas, advanced testicular cancer, breast and lung cancer and kaposi’s sarcoma. In this article, some cancer related relevant information of Vinca alkaloids are discussed.
References
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Biswas, K., Basu, J., Ghosh, A. and Giri, P. (2016). Study of rhizospheric bacterial population of Azadirachta indica (Neem) of North 24 Parganas district of West Bengal for bioprospective consideration. International Journal of Experimental Research and Review (IJERR). 6: 62-66.
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Moudi, M., Go, R., Yien, C.Y.S. and Nazre, M. (2013). Vinca alkaloids. Int. J. Prevent. Med. 4: 1231 - 1235.
Noble, R.L. (1990). The discovery of the Vinca alkaloids-chemotherapeutic agents against cancer. Biochem. Cell Biol. 68: 1344 - 1351.
Newman, D. J. and Cragg, G. M. (2016). Natural Products as Sources of New Drugs from 1981 to 2014. J. Nat. Prod. 79: 629 -661.
Oing, C., Rink, M., Oechsle, K., Seidel, C., von Amsberg, G. and Bokemeyer, C. (2016). Second line chemotherapy for advanced and metastatic urothelial carcinoma: Vinflunine and beyond-A comprehensive review of the current literature. J. Urol. 195: 254 - 263.
Pal, T. K. and Kundu, S. N. (2016). Remedial effects of aged Garlic extract during acute and chronic arsenic exposure in mice. International Journal of Experimental Research and Review (IJERR). 6: 1-11.
Sarkar, B., Jana, S. K., Kasem, S. K. and Behera, B. K. (2016). Therapeutic potential of some Medicinal plants on wound healing. International Journal of Experimental Research and Review (IJERR). 2: 1-4.
Sisodiya, P.S. (2013). Plant derived anticancer agents: A review. Int. J. Res. Develop. Pharm. Life Sci. 2: 293 -308.
Archna, Vashist, H.M., R.B. and Gupta, A. (2016). Pharmacological reputation of Vinka Plant -A review. World J. Pharm. Pharm. Sci. 5: 1602 - 1610.
Bhanot, A., Sharma, R. and Noolvi, M. N. (2011). Natural sources as potential anticancer agents: A review. Int. J. Phytomed. 3: 9 - 26.
Biswas, K., Basu, J., Ghosh, A. and Giri, P. (2016). Study of rhizospheric bacterial population of Azadirachta indica (Neem) of North 24 Parganas district of West Bengal for bioprospective consideration. International Journal of Experimental Research and Review (IJERR). 6: 62-66.
Brusotti, G., Cesari, I., Dentamaro, A., Caccialanza, G. and Massolini, G. (2014). Isolation and characterization of bioactive compounds from plant resources: the role of analysis in the ethno-pharmacological approach. J. Pharm. Biomed. Anal. 87: 218- 228.
Coderch, C., Morreale, A. and Gagol, F. (2012). Tubulin - based structure - affinity relationships for antimitotic Vinca alkaloids. Anti-Cancer Ag. Med. Chem. 12: 219 - 225.
Cragg, G. M. and Newman, D. J. (2001). Medicinal for the millennia. Ann. NY Acad. Sci. 953: 3 - 25.
Cragg, G.M. and Newman, D. J. (2005). Plants as a source of anti-cancer agents. J. Ethnopharmacol. 100: 72-79.
Gopalakrishnan, A., Panicker, Panicker, P., Gopinath, D., Vijayasaraswathy, S.G. and Kasa, J. (2014). Ethnomedicine in cancer therapy: A review. World J. Pharm. Res. 3: 305 - 319.
Gueritte, F. and Fahy, J. (2005). The Vinca alkaloids. In: Cragg, G.M., Kingston, D.G.I. and Newman, D.J. (Eds). Anticancer Agents from Natural Products. Brunner-Routledge Psychology Press, Taylor & Francis Group, Boca Raton, FL, Boca Raton, FL. Pp. 123-136 (Chapter 7).
Hadfield, J. A., Lawrence, N. J. and McGown, A.T. (1998). Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle. Med. Res. Rev. 18: 259 - 296.
Johnson, I. S., Wright, H. F., Svoboda, G. H., and Vlantis, J. (1960). Antitumor principles derived from Vinca rosea Linn I. Vincaleukoblastine and leurosine. Cancer Res. 20: 1016- 1022.
Jordan, M. A. (2002). Mechanism of action of antitumor drugs that interact with microtubules and tubulin. Curr. Med. Chem. Anticancer Ag. 2: 1-17.
Kaur, R. and Arora, S. (2015). Alkaloids - Important therapeutic secondary metabolites of plant origin. J. Crit. Rev. 2: 1- 8. Mohan, K., Jeyachandran, R. and Deepa. (2012). oids Alkal as anticancer agents. Ann. Phytomed. 1: 46 - 53.
Mandal, S. (2016). Phytochemical analysis of groundnut (Arachis hypogea L.). International Journal of Experimental Research and Review (IJERR). 6: 35-38.
Moudi, M., Go, R., Yien, C.Y.S. and Nazre, M. (2013). Vinca alkaloids. Int. J. Prevent. Med. 4: 1231 - 1235.
Noble, R.L. (1990). The discovery of the Vinca alkaloids-chemotherapeutic agents against cancer. Biochem. Cell Biol. 68: 1344 - 1351.
Newman, D. J. and Cragg, G. M. (2016). Natural Products as Sources of New Drugs from 1981 to 2014. J. Nat. Prod. 79: 629 -661.
Oing, C., Rink, M., Oechsle, K., Seidel, C., von Amsberg, G. and Bokemeyer, C. (2016). Second line chemotherapy for advanced and metastatic urothelial carcinoma: Vinflunine and beyond-A comprehensive review of the current literature. J. Urol. 195: 254 - 263.
Pal, T. K. and Kundu, S. N. (2016). Remedial effects of aged Garlic extract during acute and chronic arsenic exposure in mice. International Journal of Experimental Research and Review (IJERR). 6: 1-11.
Sarkar, B., Jana, S. K., Kasem, S. K. and Behera, B. K. (2016). Therapeutic potential of some Medicinal plants on wound healing. International Journal of Experimental Research and Review (IJERR). 2: 1-4.
Sisodiya, P.S. (2013). Plant derived anticancer agents: A review. Int. J. Res. Develop. Pharm. Life Sci. 2: 293 -308.
Published
2016-10-30
How to Cite
Sarma, M. (2016). Cancer therapy with Vinca Alkaloids. International Journal of Experimental Research and Review, 7, 38-43. Retrieved from https://qtanalytics.in/journals/index.php/IJERR/article/view/1374
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