Metal-free one-pot oxidative conversion: Molecular Iodine Mediated Oxidation Organic Reactions

Swapan Kumar Biswas; Titas Biswas

doi:10.52756/ijerr.2022.v27.005

Authors

Swapan Kumar Biswas Department of Chemistry, Sree Chaitanya College, Habra, North 24 Parganas, West Bengal, India https://orcid.org/0000-0002-2757-7702
Titas Biswas Department of Chemistry, Gurudas College, Kolkata-700054, West Bengal, India https://orcid.org/0000-0001-7926-9106

DOI:

https://doi.org/10.52756/ijerr.2022.v27.005

Keywords:

Aldehyde, alkyne oxidation, halogen, molecular iodine catalysis, ketone ester and carboxylic acid, pyridine-N-oxide

Abstract

Various oxidative compounds such as aldehyde, ketone ester, and acids can be produced in large yields by an effective iodine-mediated oxidative reaction of organic molecules. Molecular iodine is a generally available and commercially extremely inexpensive substance that induces oxidative esterification. With the comparison with different Brønsted acid catalysis, molecular iodine or iodophilic activations proceed the reaction onto a deoxygenation pathway. With only a few mol% of I₂, the oxidation occurs very quickly at room temperature. This approach could also be used to transport different benzil derivatives from nonactivated alkynes, such as diaryl acetylenes. Molecular iodine with several mild reagents such as aq. NH₃, ?30% aq. H₂O₂ and DMSO might be used to convert various one degree alcohols, particularly benzylic alcohols, into the corresponding aromatic amides in suffiently high yields in a one-pot method. Similarly, by treating different benzylic chloride, bromide and iodide with a molecular iodine oxidation medium, the corresponding aromatic amides may be prepared in a one-pot method. The reactions in this section include transformation of several compounds into their respective oxidative products with the metal-free one-pot oxidative.

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