Review on Phyto-chemistry & pharmacological activity of Melia azedarach

  • Durgesh Ranjan Kar Bengal School Technology (A College of Pharmacy), Chuchura, Hooghly, West Bengal, India https://orcid.org/0000-0003-3524-6273
  • Priojit Ghosh Bengal School Technology (A College of Pharmacy), Chuchura, Hooghly, West Bengal, India
  • Padilam Suresh Bengal School Technology (A College of Pharmacy), Chuchura, Hooghly, West Bengal, India
  • Shaibal Chandra Bengal School Technology (A College of Pharmacy), Chuchura, Hooghly, West Bengal, India
  • Dhrubakishore Paul Bengal School Technology (A College of Pharmacy), Chuchura, Hooghly, West Bengal, India
Keywords: Antibacterial activity, antifertility activity, flavonoids, steroids, medicinal plant, Melia azedarach

Abstract

Medicinal plants as essential additives in foods, beverages, and medications have been a part of human culture since the dawn of time. Medicinal plants' nutritional, pharmacological, biological, and toxicological characteristics have numerous applications in numerous industries. Nowadays, most people rely on complementary and alternative therapies to treat various illnesses derived from natural sources. Melia azedarach is one of the plants (Meliaceae family) grown in numerous Indian states. The entire plant or its parts (leaves, stem and roots) have medicinal characteristics and have been used by native and tribal people in various parts of India for a very long time. This plant has traditionally been used to cure various conditions, including piles, itching, asthma, leprosy, and cough. The current study includes a comprehensive analysis of its systematic botanical position, phytochemical analysis, research on the plant's pharmacological activity, and medicinal applications.

References

Abbasi, A.M., Khan, M.A, Ahmed, M., & Zafar M. (2010). Herbal medicine used to cure various ailments by the inhabitants of Abbottabad District, North West Frontier Province. Ind. J. Trad. Know. 9(1): 175-183.

Azam, M.M., Mamun-Or-Rashid, A.N.M., Towfique, N.M., Sen, M.K., & Nasrin, S. (2013). Pharmacological potentials of Melia azedarach L.-A review. American Journal of BioScience. 1(2): 44-49.

Asadujjaman, M., Saed, A., Hossain, M.A., & Karmakar, U.K. (2013). Assessment of bioactivities of ethanolic extract of Melia azedarach (Meliaceae) leaves. Journal of Coastal Life Medicine. 1(2): 118-122.

Alche, L.E., Ferek, G.A., Meo, M., Coto, C.E., & Maier, M.S. (2001). An antiviral meliacarpin from leaves of Melia azedarach L. Verlag der Zeitschrift fur Naturforschung Tubingen. 58: 215-219.

Ahmed, M.F., Rao, A.S., Ahemad, S.R., & Ibrahim, M. (2012). Phytochemical studies and antioxidant activity of Melia azedarach Linn leaves by DPPH scavenging Assay. Int. J. Pharma. Appl. 3: 271-276.

Baser, K.H.C (2008). Biological and Pharmacological Activities of Carvacrol and Carvacrol Bearing Essential Oils. Current Pharmaceutical Design. 14(29): 3106 – 3119.

Benencia, F., Courreges, M.C., Coto, C., & Coulombie, F.C. (1997). Immunomodulatory activities of Melia azedarach L. leaf extracts on human monocytes. J. Herb Spices and Med. Plants. 5(3): 7-13.

Bhardwaj, R., Yadav, A., & Sharma, A. (2014). In vitro and in vivo GC-MS Profile and Antimicrobial Activity of Phytosterols of Datura stramonium. Research Journal of Medicinal Plant. 8(3): 112-120.

Charturvedi, R. P., & Ntshebe, B.H.O. (2006). Antimalarial activity of Melia azedarach. J App. Zoolo. Res. 17: 109- 113.

Chauhan, M., Mani, P., & Sharma, T. K. (2018). The Antibacterial Activities of Neem [Azadirachta Indicia] Seed Oil-A Review. IOSR Journal of Applied Chemistry. 11(5): 58-63.

Christina, A.J.M., Najumadeen, N.A.H., Kumar, S.V., Mainikandan, N., Tobin, G.C., Venkataraman, S., & Murugesh, N. (2006). Antilithiatic effect of on Melia azedarach ethylene glycol-induced nephrolithiasis in rats. Pharma. Biol. 44: 480 - 485.

Efe, B., Galata,Y. F., & Arslan, Y. E. (2018). Assessment of the Cytotoxicity of Melia azedarach L. Extracts on Human Adipose-derived Mesenchymal Stem Cells. B. Efe / Hacettepe J. Biol. & Chem. 46 (1): 121–128.

El-Lakwah, F.A., Mohamed, R., & Darwish, A.A. (1995). Evaluation of toxic effect of chinaberry. Annals of Agri. Sci. 33(1): 389-398.

Ervina, M., & Sukardiman. (2018). A review: Melia azedarach L. as a potent anticancer drug. Pharmacognosy Reviews.12(23): 94

Jafari, S., Saeidnia, S., Hajimehdipoor, H., Ardekani, S.M.R., & Faramarzi, M.A. (2013). Hadjiakhoond A. and Khanavi M. Cytotoxic evaluation of Melia azedarach in comparison with, Azadirachta indica and its phytochemical investigation. DARU J. Pharma. Sci. 1: 21-37.

Kaur, N., Chaudhary, J., Jain, A., & Kishore, L. (2011). Stigmasterol: a comprehensive review. International Journal of Pharmaceutical Sciences and Research. 2(9): 2259-2265.

Kaur, R., Sharma, A., Kumar, R., & Kharb, R. (2011). Rising Trends towards Herbal Contraceptives. J. Nat. Prod. Plant Resour. 1(4):5-12.

Kayastha, B.P. (1985). Silvics of the trees of Nepal. Community Forest Development Project, Kathmandu. 2: 189-196.

Khan, A.V., Ahmed, Q.U., Mir, M.R., Shukla, I., & Khan, A.A. (2011). Antibacterial efficacy of the seed extracts of Melia azedarach against some hospital isolated human pathogenic bacterial strains. Asian Pacific J. Trop. Biomed. 1: 452-455.

Kim, J.K., & Park, S.U. (2020). Recent studies on Kaempferol and its biological and Pharmacological activities. Excli. Journal. 19: 627-634.

Lee, B.G., Kim, S.H., Zee, O.P., Lee, K.R., Lee, H.Y., Hana, J.W., & Lee, W.H. (2000). Suppression of inducible nitric oxide synthase expression in RAW 264.7 macrophages by two b-carboline alkaloids extracted from Melia azedarach. European J. Pharmacol. 406: 301–309.

Lee, Y.S., Chung, I.B., Choi, W.H., Cho, Y.J., Chu, J.P., Min, B.I., & Shin, E.H. (2007). Inhibitory effects of Melia azedarach L. extracts on the growth of Trichomonus vaginalis Ultrastructural changes of Trichomonu vaginalis by Melia azedarach L. J. Protozool. Res. 17: 16-24.

Malar, T.R.J.J., Antonyswamy, J., Vijayaraghavan, P., Kim, Y. O., Al-Ghamdi, A.A., Elshikh, M.S., Hatamleh, A.A., Al-Dosary, M.A., Na, S.W., & Kim, H.J. (2020). In-vitro phytochemical and pharmacological bio-efficacy studies on Azadirachta indica A. Juss and Melia azedarach Linn for anticancer activity. Saudi J. Biol. Sci. 27(2): 682–688.

Moursi, S.A.H., & AL-Khatib, I.M.H. (1984). Effect of Melia azedarach fruits on Gipsing - restraint stress-induced Ulcers in rats. Japan J. Pharmacol. 36: 527 – 533.

Munir, A., Sultana, B., Babar, T., Bashir, A., Amjad, M., & Hassan, Q. (2012). Investigation on the Antioxidant Activity of Leaves, Fruit and Stem Bark of Dhraik (Melia azedarach). European J. Appl. Sci. 4: 47-51.

Mustapha, N.A., & Runner, R.T.M. (2016). GC-MS Analysis and Preliminary Antimicrobial Activity of Albizia adianthifolia (Schumach) and Pterocarpus angolensis (DC). Medicines. 3(3): 2-9.

Qarabadeen, J. (2005). Central Council for Research in Unani Medicine. New Delhi, Pp. 90-105 & 181.

Rhaymah, M.S.H. (2006). Anticomplementary activities of aqueous extract of the fruit of Melia azedarach and Cotoneaster prostratae in rats. J. Animal.Vet. Adv. 5: 197-199.

Rigoberto, V.G., Rodolfo, A.V., Vera, L.P. (2017). Chemical compounds and biological activity of an extract from Bougainvillea X Buttiana (Var. Rose) Holttum and Standl. International Journal of Pharmacy and Pharmaceutical Sciences. 9(3): 42-46.

Rishi, K., & Singh, R. (2003). Chemical components and insecticidal properties of Bakain (Melia azedarach L.) - A Review. Agri. Rev. 24(2): 101-115.

Roop, J.K., Dhaliwal, P.K., & Guraya, S.S. (2005). Extracts of Azadirachta indica and Melia azedarach seeds inhibit folliculogenesis in albino rats. Plant extracts inhibit rat folliculogenesis. Brazilian J. Med. Biol. Res. 38: 943-947.

Saleem, R., Ahmed, S.I., Faizi, S., & Siddiqui, B.S. (2002). Antibacterial effect of Melia azedarach on rabbits. Phytother. Res. 16: 762-4.

Saleem, R., Rani, R., Ahmed, M., Sadaf, F., Ahmad, S.I., Zafar, N., Khan, S.S., Siddiqui, B.S., Lubna, F., Ansari, S.A. K., & Faizi, S. (2008). Effect of a cream containing Melia azedarach flowers on skin diseases in children. Phytomed. 15: 231- 236.

Rana, S., & Asemi, Z. (2019). Quercetin: a natural compound for ovarian cancer treatment. J. Ovarian Res. 12(1): 55. doi: 10.1186/s13048-019-0530-4

Shakib, U. (2020). Pharmacological activities of neem (Azadirachta indica): A review. International Journal of Pharmacognosy and Life Science. 1(1): 38-41.

Sharma, D., & Paul, Y. (2013). Preliminary and Pharmacological Profile of Melia azedarach L.: An Overview. Journal of Applied Pharmaceutical Science. 3(12): 133-138.

Shrishkumar, D., & Ambavade, P.D. (2014). Ambavade. Pharmacological, nutritional, and analytical aspects of β-sitosterol: a review. Oriental Pharmacy & Experimental Medicine. 14(3): 193-221.

Singh, B., Pandya, D., & Mankad, A. (2020). A Review on Different Pharmacological & Biological Activities of Azadirachta indica A. Jusm. and Melia azedarach L. Jour. Pl. Sci. Res. 36(1-2): 53-59.

Srivastava, S.K., Agrawal, B., Kumar, A., & Pandey, A. (2020). Phytochemicals of Azadirachta indica source of active medicinal constituent used for cure of various diseases: A Review. Journal of Scientific Research. 64(1): 385-390.

Sultana, S., Akhtar, N., & Asif, H.M. (2013). Phytochemical screening and Antipyretic effects of Hydromethanol extract of Melia azedarach leaves in rabbits. Bangladesh J. Pharmacol. 8: 214-217.

Sultana, S., Asif, H.M., Akhtar, N., Waqas, M., & Rehma, S.U. (2014). Comprehensive review on ethanobotanical uses, phytochemistry and pharmacological properties of Melia azedarach Linn. Asian J. Pharmaceut. Res. Health Care. 6(1): 26-32.

Suresh, K., Deepa, P., Harisaranraj, R., & Vaira A.V. (2008). Antimicrobial and Phytochemical investigation of the leaves of Carica papaya L., Cynodon dactylon L. Pers., Euphorbia Hirta L., Melia azedarach L. and Psidium guajava L. Ethnobotanical Leaflets. 2: 1184-1191.

Szewezuk, V.D., Mongelli, E.R., & Pomilio, A.B. (2003). Antiparasitic activity of Melia azedarach growing in Argentina. Mol. Med. Chem.1: 5457.

Sultana, S., Asif, F., Naveed, A., Waqas, M., & Rehman, S. (2014). Comprehensive review on ethanobotanical uses, phytochemistry and pharmacological properties of Melia azedarach Linn. Asian Journal of Pharmaceutical Research and Health Care. 6(1): 26-32.

Vidya, V., & Srinivasan, S. (2012). Wound healing potential of Melia azedarach L. leaves in alloxan induced diabetic rats. Global J. Res. Med. Plants & Indi. Med. 1: 265-271.

Vishnukanta., & Rana, A.C. (2008). Melia azedarach: A phytopharmacological review. 2(3): 173-179.

Wachsman, M.B., Castilla, V., & Coto, C. (1998). Inhibition of foot and mouth disease virus (FMDV) uncoating by plant - derived peptide isolated from Melia azedarach L. Leaves. Arch. Virod. 143: 581-590.

Zih-Rou, H., Yin-Ku, L., & Jia,Y. F. (2009). Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic. Dermatology Molecules. 14: 540-554.

Published
2022-08-30
How to Cite
Kar, D., Ghosh, P., Suresh, P., Chandra, S., & Paul, D. (2022). Review on Phyto-chemistry & pharmacological activity of Melia azedarach. International Journal of Experimental Research and Review, 28, 38-46. https://doi.org/10.52756/ijerr.2022.v28.006
Section
Articles