Therapeutic Potential of Polyherbal Tablets: A Comprehensive Assessment of Pharmacological Activity

Abstract

Azadirachta indica, Allium sativum and Annona squamosa are widely recognized medicinal plants with significant therapeutic potential. Individually, each of these plants has been historically acclaimed for its antidiabetic properties, but the synergistic effect of a combined formulation has remained largely unexplored. This research aims to evaluate the antidiabetic potential of a polyherbal formulation consisting of these three plants in streptozotocin-induced diabetic rats. The polyherbal formulation was prepared using ethanolic extracts of the leaves of Azadirachta indica, bulbs of Allium sativum, and leaves of Annona squamosa. The formulation was standardized as per the World Health Organization's guidelines for herbal materials. Acute toxicity studies established its safety profile, showing no toxicity at doses up to 2000 mg/kg. Antidiabetic activity was assessed in streptozotocin-induced diabetic rats, and the results demonstrated a remarkable reduction in blood glucose levels, comparable to the standard drug glibenclamide. Furthermore, biochemical evaluations corroborated the formulation's efficacy, which was also substantiated through histopathological assessments of the liver and pancreas. In conclusion, the polyherbal formulation exhibits profound antidiabetic activity, suggesting its potential as an effective herbal remedy for diabetes management.