Deep Learning Models for Accurate Diagnosis and Detection of Bone Pathologies: A Comprehensive Analysis and Research Challenges

  • Harshit Vora Department of Computer Engineering, Indus University, Ahmedabad, Gujarat, India
  • Seema Mahajan Department of Computer Engineering, Indus University, Ahmedabad, Gujarat, India
  • Yogesh Kumar Pandit Deendayal Energy University, Gandhinagar https://orcid.org/0000-0002-2879-0441
Keywords: Artificial intelligence, bone disorder, convolutional neural network, learning models, medical imaging

Abstract

The presence of bone disease has been observed to have a substantial influence on an individual's overall health. There are conventional techniques to detect as well as diagnose them but they often suffer limitations in the form of misdiagnosis because of manual error as well as maximum time consumption. Therefore, it is of utmost importance to accurately and proficiently identify it by integrating conventional methods with advanced artificial intelligence techniques. The objective of this study is to conduct a comprehensive analysis of the present state of research concerning the identification and diagnosis of bone disease using machine learning and deep learning. A review is conducted in accordance with the PRISMA guidelines which focus on the examination of scholarly articles published within the timeframe of 2019 to 2024. This review analyzes peer-reviewed literature and research findings to show how machine and deep learning can improve bone disease diagnosis accuracy. It has been found that in the case of osteoporosis, the highest recall, precision, and F1 score is computed by random forest with 93%, 94%, and 93%, respectively while as advanced CNN technique computed 98% accuracy for osteoporosis and 98.4% accuracy, 95% sensitivity as well as 97% specificity for osteonecrosis. Likewise, for bone tumor and osteoarthritis, AlexNet achieved 98% and 98.90% accuracy, respectively. The study introduces a novel approach to the diagnosis of bone diseases by emphasizing the usage of advanced learning techniques over conventional methods. Additionally, the paper highlights the significance of analyzing the clinical or imaging data and extracting features to improve image quality and provide a pathway toward more accurate and efficient diagnosis of bone diseases. By delving into these techniques, the paper offers valuable insights into enhancing diagnostic capabilities for bone diseases, which ultimately leads to improved patient care and treatment outcomes.

References

Abdullah, S. S., & Rajasekaran, M. P. (2022). Automatic detection and classification of knee osteoarthritis using deep learning approach. La Radiologia Medica, 127(4), 398-406. https://doi.org/10.1007/s11547-022-01476-7

Ahmad, A., Crawford III, C. H., Glassman, S. D., Dimar II, J. R., Gum, J. L., & Carreon, L. Y. (2023). Correlation between bone density measurements on CT or MRI versus DEXA scan: a systematic review. North American Spine Society Journal (NASSJ), 14, 100204. https://doi.org/10.1016/j.xnsj.2023.100204

Bagaria, R., Wadhwani, S., & Wadhwani, A. K. (2021). A wavelet transform and neural network based segmentation & classification system for bone fracture detection. Optik, 236, 166687. https://doi.org/10.1016/j.ijleo.2021.166687

Bansal, M., Kumar, M., & Kumar, M. (2021). 2D object recognition: a comparative analysis of SIFT, SURF and ORB feature descriptors. Multimedia Tools and Applications, 80(12), 18839-18857.

Campagne, D. (2022). Overview of Fractures. MSD Manual Consumer Version. https://www.msdmanuals.com/en-in/home/injuries-and-poisoning/fractures/overview-of-fractures

Changela, A., Kumar, Y., & Koul, A. (2023). Automated System to Diagnose and Detect the Allergy, Common Cold, Flu, and Covid using Machine Learning Approaches. IEEE, In 2023 International Conference on Communication, Security and Artificial Intelligence (ICCSAI), pp. 1-6. https://doi.org/10.1109/ICCSAI59793.2023.10421400

Gautam, S., Ahlawat, S., & Mittal, P. (2022). Binary and Multi-class Classification of Brain Tumors using MRI Images. Int. J. Exp. Res. Rev., 29, 1-9. https://doi.org/10.52756/ijerr.2022.v29.001

Georgeanu, V. A., Mămuleanu, M., Ghiea, S., & Selișteanu, D. (2022). Malignant bone tumors diagnosis using magnetic resonance imaging based on deep learning algorithms. Medicina, 58(5), 636. https://doi.org/10.3390/medicina58050636

Htun, N. T., & Tun, K. M. M. (2023, July). Automatic Detection and Classification of Tibia Bone Fracture from X-ray Images by using Gray Level Co-occurrence Matrix. IEEE, In 2023 14th International Conference on Computing Communication and Networking Technologies (ICCCNT), pp. 1-5.

https://doi.org/10.1109/ICCCNT56998.2023.10307328

Hung, T. N. K., Le, N. Q. K., Le, N. H., Van Tuan, L., Nguyen, T. P., Thi, C., & Kang, J. H. (2022). An ai‐based prediction model for drug‐drug interactions in osteoporosis and Paget's diseases from smiles. Molecular Informatics, 41(6), 2100264. https://doi.org/10.1002/minf.2021002643

Kanimozhi, S., & Chintanpalli, A. (2024). Recent Advancements in Feature Extraction and Classification Based Bone Cancer Detection. http://dx.doi.org/10.2139/ssrn.4689326

Karanam, S. R., Srinivas, Y., & Chakravarty, S. (2022). A systematic approach to diagnosis and categorization of bone fractures in X-Ray imagery. International Journal of Healthcare Management, pp. 1-12. https://www.tandfonline.com/doi/pdf/10.1080/20479700.2022.2097765

Kaur, I., Sandhu, A. K., & Kumar, Y. (2022). Utilizing deep transfer learning models and data augmentation to improve image classification. Mathematical Statistician and Engineering Applications, 71(3), 1923-1932. https://doi.org/10.17762/msea.v71i3.1515

Kerketta, S. R., & Ghosh, D. (2021). Detection of onset and progression of osteoporosis using machine learning. Machine Learning for Healthcare Applications, pp. 137-149. https://doi.org/10.1002/9781119792611.ch9

Khojastepour, L., Hasani, M., Ghasemi, M., Mehdizadeh, A. R., & Tajeripour, F. (2019). Mandibular trabecular bone analysis using local binary pattern for osteoporosis diagnosis. Journal of Biomedical Physics & Engineering, 9(1), 81. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409375/

Koul, A., Bawa, R. K., & Kumar, Y. (2022). Artificial intelligence in medical image processing for airway diseases. Cham: Springer International Publishing, In Connected e-Health: Integrated IoT and cloud computing, pp. 217-254. https://doi.org/10.1007/s11831-022-09818-4

Koul, A., Bawa, R. K., & Kumar, Y. (2023). Artificial intelligence techniques to predict the airway disorders illness: a systematic review. Archives of Computational Methods in Engineering, 30(2), 831-864. https://doi.org/10.1007/s11831-022-09818-4

Koul, A., Bawa, R. K., & Kumar, Y. (2024). An analysis of deep transfer learning-based approaches for prediction and prognosis of multiple respiratory diseases using pulmonary images. Archives of Computational Methods in Engineering, 31(2), 1023-1049. https://doi.org/10.1007/s11831-023-10006-1

Koul, A., Bawa, R. K., & Kumar, Y. (2024). Enhancing the detection of airway disease by applying deep learning and explainable artificial intelligence. Multimedia Tools and Applications, pp. 1-33. https://doi.org/10.1007/s11042-024-18381-y

Küçükçiloğlu, Y., Şekeroğlu, B., Adalı, T., & Şentürk, N. (2024). Prediction of osteoporosis using MRI and CT scans with unimodal and multimodal deep-learning models. Diagnostic and Interventional Radiology, 30(1), 9. https://doi.org/10.4274/dir.2023.232116

Kumar, Y., Garg, P., Moudgil, M. R., Singh, R., Woźniak, M., Shafi, J., & Ijaz, M. F. (2024). Enhancing parasitic organism detection in microscopy images through deep learning and fine-tuned optimizer. Scientific Reports, 14(1), 5753. https://doi.org/10.1038/s41598-024-56323-8

Li, L., Jin, X., Liu, S., & Fan, H. (2024). Prenatal ultrasound findings and prenatal diagnosis of fetal skeletal dysplasia. Journal of Clinical Ultrasound. https://doi.org/10.1002/jcu.23673

Link, T. M., & Kazakia, G. (2020). Update on imaging-based measurement of bone mineral density and quality. Current Rheumatology Reports, 22, 1-11. https://doi.org/10.1007/s11926-020-00892-w

Machine Learning Datasets. https://paperswithcode.com/datasets?q=Fracture%2FNormal%20Shoulder%20Bone%20X-ray%20Images%20on%20MURA

Mondal, S., Nag, A., Barman, A., & Karmakar, M. (2023). Machine Learning-based maternal health risk prediction model for IoMT framework. Int. J. Exp. Res. Rev., 32, 145-159. https://doi.org/10.52756/ijerr.2023.v32.012

Noguchi, S., Nishio, M., Sakamoto, R., Yakami, M., Fujimoto, K., Emoto, Y., ... & Nakamoto, Y. (2022). Deep learning–based algorithm improved radiologists’ performance in bone metastases detection on CT. European Radiology, 32(11), 7976-7987. https://doi.org/10.1007/s00330-022-08741-3

Pan, J., Lin, P. C., Gong, S. C., Wang, Z., Cao, R., Lv, Y., ... & Wang, L. (2024). Effectiveness of opportunistic osteoporosis screening on chest CT using the DCNN model. BMC Musculoskeletal Disorders, 25(1), 176. https://doi.org/10.1186/s12891-024-07297-1

Prasad, R., Musa, F., Ahmad, H., Upadhyay, S., & Sharma, B. (2024). Autism Spectrum Disorder Prediction Using Machine Learning and Design Science. International Journal of Experimental Research and Review, 39(Spl Volume), 213-228. https://doi.org/10.52756/ijerr.2024.v39spl.017

Ramesh, T., & Santhi, V. (2024). Multi-level classification technique for diagnosing osteoporosis and osteopenia using sequential deep learning algorithm. International Journal of System Assurance Engineering and Management, 15(1), 412-428. https://doi.org/10.1007/s13198-022-01760-9

Raza, A., Phan, T. L., Li, H. C., Hieu, N. V., Nghia, T. T., & Ching, C. T. S. (2024). A Comparative Study of Machine Learning Classifiers for Enhancing Knee Osteoarthritis Diagnosis. Information, 15(4), 183. https://doi.org/10.3390/info15040183

Saha, A., & Yadav, R. (2023). Study on segmentation and prediction of lung cancer based on machine learning approaches. Int. J. Exp. Res. Rev., 30, 1-14. https://doi.org/10.52756/ijerr.2023.v30.001

Sampath, K., Rajagopal, S., & Chintanpalli, A. (2024). A comparative analysis of CNN-based deep learning architectures for early diagnosis of bone cancer using CT images. Scientific Reports, 14(1), 2144. https://doi.org/10.1038/s41598-024-52719-8

Santhakumar, S. (2023). What to know about bone diseases. https://www.medicalnewstoday.com/articles/bone-diseases

Sharma, A., Mishra, A., Bansal, A., & Bansal, A. (2021). Bone fractured detection using machine learning and digital geometry. Springer Singapore, In Mobile Radio Communications and 5G Networks: Proceedings of MRCN 2020, pp. 369-376. https://doi.org/10.1007/978-981-15-7130-5_28

Shen, X., Luo, J., Tang, X., Chen, B., Qin, Y., Zhou, Y., & Xiao, J. (2023). Deep learning approach for diagnosing early osteonecrosis of the femoral head based on magnetic resonance imaging. The Journal of Arthroplasty, 38(10), 2044-2050. https://doi.org/10.1016/j.arth.2022.10.003

Shim, J. G., Kim, D. W., Ryu, K. H., Cho, E. A., Ahn, J. H., Kim, J. I., & Lee, S. H. (2020). Application of machine learning approaches for osteoporosis risk prediction in postmenopausal women. Archives of Osteoporosis, 15, 1-9. https://doi.org/10.1007/s11657-020-00802-8

Shorten, C., & Khoshgoftaar, T. M. (2019). A survey on image data augmentation for deep learning. Journal of Big Data, 6(1), 1-48. https://doi.org/10.1186/s40537-019-0197-0

Shrivastava, A., & Nag, M. K. (2024). Enhancing bone cancer diagnosis through image extraction and machine learning: a state-of-the-art approach. Surgical Innovation, 31(1), 58-70. https://doi.org/10.1177/15533506231220968

Singh, J., Sandhu, J. K., & Kumar, Y. (2024). Metaheuristic-based hyperparameter optimization for multi-disease detection and diagnosis in machine learning. Service Oriented Computing and Applications, 1-20. https://doi.org/10.1007/s11761-023-00382-8

Singh, D., & Singh, S. (2023). Precision fault prediction in motor bearings with feature selection and deep learning. Int. J. Exp. Res. Rev., 32, 398-407. https://doi.org/10.52756/ijerr.2023.v32.035

Srivastava, R., & Tripathi, M. (2023). Systematic Exploration Using Intelligent Computing Techniques for Clinical Diagnosis of Gastrointestinal Disorder: A Review. Int. J. Exp. Res. Rev., 36, 265-284. https://doi.org/10.52756/ijerr.2023.v36.026

Tu, J. B., Liao, W. J., Liu, W. C., & Gao, X. H. (2024). Using machine learning techniques to predict the risk of osteoporosis based on nationwide chronic disease data. Scientific Reports, 14(1), 1-11. https://doi.org/10.1038/s41598-024-56114-1

von Schacky, C. E., Wilhelm, N. J., Schäfer, V. S., Leonhardt, Y., Jung, M., Jungmann, P. M., ... & Gersing, A. S. (2022). Development and evaluation of machine learning models based on X-ray radiomics for the classification and differentiation of malignant and benign bone tumors. European radiology, 32(9), 6247-6257. https://doi.org/10.1007/s00330-022-08764-w

Wang, P., Liu, X., Xu, J., Li, T., Sun, W., Li, Z., ... & An, Y. (2021). Deep learning for diagnosing osteonecrosis of the femoral head based on magnetic resonance imaging. Computer Methods and Programs in Biomedicine, 208, 106229. https://doi.org/10.1016/j.cmpb.2021.106229

Wawrzyniak, A., & Balawender, K. (2022). Structural and metabolic changes in bone. Animals, 12(15), 1946. https://doi.org/10.3390/ani12151946

Yavanamandha, P., Keerthana, B., Jahnavi, P., Rao, K. V., & Kumar, C. R. (2023). Machine Learning-Based Gesture Recognition for Communication with the Deaf and Dumb. Int. J. Exp. Res. Rev., 34(Special Vol.), 26-35. https://doi.org/10.52756/ijerr.2023.v34spl.004

Zaki, M. Z. A. A., Som, M. H. M., Yazid, H., Basaruddin, K. S., Basah, S. N., & Ali, M. S. A. M. (2021, October). A Review on Edge Detection on Osteogenesis Imperfecta (OI) Image using Fuzzy Logic. IOP Publishing, In Journal of Physics: Conference Series, 2071(1), 012040. https://doi.org/10.1088/1742-6596/2071/1/012040

Published
2024-06-30
How to Cite
Vora, H., Mahajan, S., & Kumar, Y. (2024). Deep Learning Models for Accurate Diagnosis and Detection of Bone Pathologies: A Comprehensive Analysis and Research Challenges. International Journal of Experimental Research and Review, 40(Spl Volume), 117-131. https://doi.org/10.52756/ijerr.2024.v40spl.009