Circular RNAs: Therapeutic Uses in Colorectal Cancer

Muthusamy Thangavel; Chalini Vijayakumar; Deepalakkshmi Balakrishnan

doi:10.52756/ijerr.2024.v45spl.022

Authors

Muthusamy Thangavel Research and Development Wing, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chromepet, Chennai-600044, Tamil Nadu, India https://orcid.org/0000-0002-4955-670X
Chalini Vijayakumar Research and Development Wing, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chromepet, Chennai-600044, Tamil Nadu, India https://orcid.org/0009-0006-7167-4661
Deepalakkshmi Balakrishnan Research and Development Wing, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chromepet, Chennai-600044, Tamil Nadu, India https://orcid.org/0000-0003-4008-5101

DOI:

https://doi.org/10.52756/ijerr.2024.v45spl.022

Keywords:

Circular RNAs, Therapeutic Applications, Colorectal Cancer, Clinical Significance of Circular RNA

Abstract

Circular RNA (circRNA) emerges as a significant sub-type of single-stranded non-coding RNA within colorectal cancer (CRC), boasting high abundance. Delving into research, numerous pivotal roles of circRNA in therapeutic contexts within CRC have come to light, encompassing areas such as metastasis, apoptosis, and proliferation. Moreover, circRNAs exhibit significant involvement in the advancement of therapeutic strategies, demonstrating unique correlations with tumor staging, size and overall survival rates in colorectal cancer. These associations position circRNAs as potential candidates for both anticancer interventions and prognostic biomarkers. Among all cancers, colorectal cancer is the second most prevalent cause of cancer-related death and the third most common disease to be diagnosed worldwide. To gain deeper insights into the impact of circRNA-based therapeutic developments on CRC and its progression, this comprehensive review aims to synthesize the roles of specific therapeutic applications targeting circRNAs in CRC. It also aims to evaluate circRNAs' potential as useful therapeutic targets and prognostic indicators in the context of colorectal cancer. The overarching goal of this review is to illuminate the landscape of therapeutic strategies and aid in clinical decision-making processes related to CRC. By elucidating the intricate interplay between circRNAs and therapeutic interventions, this review seeks to contribute to the advancement of therapeutic modalities and improve patient outcomes in the realm of colorectal cancer management.

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