Predictive risk assessment of a common food additive monosodium glutamate : An in vivo biochemical, patho-physiological and molecular study
Keywords:
Food additive, mice, MSG, SDS-PAGE
Abstract
Monosodium glutamate (MSG) is a popular food additive commonly known as Ajinomoto, which has a flavour enhancing effect on food. We investigated if the MSG has any potential to alter kidney and liver function and biochemical and molecular changes in mice. Healthy mice weighing between 20 and 25 grams were chosen for the biochemical, patho-physiological, and molecular studies. Mice were fed with MSG at the dose 2 mg / gm of b.w. There were reduced levels of blood glucose, total serum protein, serum albumin, urea, and BUN and increased level of creatinine, The present findings suggest that MSG has toxic effects on kidney and liver.
References
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Lowry, O. H., Rosebrough, N. J. and Farr, A. L. and Randall, R. J. (1951). Protein measurement with Folin-Phenol reagent. J. Biol. Chem. 193: 265-275.
Nagasawa, H., Yanai, R. and Kikuyama, S. (1974) Irreversible inhibition of pituitary prolactin and growth hormone secretion and of mammary gland development in mice by monosodium glutamate administered neonatally. Acta Endocrinol. 75: 249- 259.
Pramanik, S. and Karmakar, S. R. (2016). Cytotoxic and genotoxic effects of a common food additive monosodium glutamate in mice: a preliminary report. International Journal of Experimental Research and Review. 8: 98-103.
Bunyan, J., Murrell, E. A. and Shah, P. P. (1976). The induction of obesity in rodents by means of monosodium glutamate. British J. Nutr. 35: 25-39.
Das, R. S. and Ghosh, S. K. (2010). Long term effects of monosodium glutamate on spermatogenesis following neonatal exposure in albino mice – a histological study. Nepal Med. Coll. J. 12(3): 149-153.
Eweka, A. O. and Om'iniabohs, F. A. E. (2011). Histological studies of the effects of monosodium glutamate on the ovaries of adult wistar rats. Annal of Medical & Health Sciences Research. 1(1): 37-43.
Fisher, R. A. and Yates, F. (1953). Statistical tables for Biological, Agricultural and Medical Research. 4th Edition. Oliver and Boyd, Edinburgh.
Fuke, S. and Shimizu, T. (1993). Sensory and preference aspects of umami. Trends in Food Sci. & Technol. 4: 246-251.
Garattiini, S. (2000). Glutamic Acid, Twenty Years Later. J. Nutr. 130(4S Suppl): 901S-909S.
Lowry, O. H., Rosebrough, N. J. and Farr, A. L. and Randall, R. J. (1951). Protein measurement with Folin-Phenol reagent. J. Biol. Chem. 193: 265-275.
Nagasawa, H., Yanai, R. and Kikuyama, S. (1974) Irreversible inhibition of pituitary prolactin and growth hormone secretion and of mammary gland development in mice by monosodium glutamate administered neonatally. Acta Endocrinol. 75: 249- 259.
Pramanik, S. and Karmakar, S. R. (2016). Cytotoxic and genotoxic effects of a common food additive monosodium glutamate in mice: a preliminary report. International Journal of Experimental Research and Review. 8: 98-103.
Published
2017-04-30
How to Cite
Pramanik, S., & Karmakar, S. (2017). Predictive risk assessment of a common food additive monosodium glutamate : An in vivo biochemical, patho-physiological and molecular study. International Journal of Experimental Research and Review, 10, 37-43. Retrieved from https://qtanalytics.in/journals/index.php/IJERR/article/view/1298
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